Saito T, Sitan N
Jpn J Antibiot. 1979 Nov;32(11):1183-8.
In the course of treating twenty patients with acute urinary tract infections, the toxicity and efficacy of a small dosage regimen (50 mg p.o., t.i.d.) of minocycline were evaluated. No vestibular symptoms attributable to minocycline treatment were observed in any of the cases entered in this study. Adverse reactions included mild nausea in 1 case and urticaria in another case. Minocycline with this dosage regimen sterilized the urine of 90% of patients with acute urinary tract infections.
在治疗20例急性尿路感染患者的过程中,评估了小剂量米诺环素方案(口服50毫克,每日三次)的毒性和疗效。在本研究纳入的任何病例中均未观察到归因于米诺环素治疗的前庭症状。不良反应包括1例轻度恶心和另1例荨麻疹。采用该剂量方案的米诺环素使90%的急性尿路感染患者尿液除菌。