Rogers J H, Barnwell P A, Waterman N G, Austin F D, Raff M J
Int J Clin Pharmacol Biopharm. 1977 Apr;15(4):194-8.
24 patients with severe infections were treated with intravenous minocycline 100 mg every 12 hours. Average blood levels were within therapeutic ranges during the first 12 hours after the initial dose. Determination of efficacy of therapy in 23 of the patients who were evaluable showed that clinical and bacteriological results were satisfactory in 20 patients, unsatisfactory in 2, and questionable in 1. One patient developed a fatal secondary infection which may have been related to prior therapy with minocycline. No toxicities or side-effects were observed.
24例严重感染患者接受静脉注射米诺环素治疗，每12小时100毫克。首剂给药后的最初12小时内，平均血药浓度处于治疗范围内。对23例可评估患者的治疗效果进行测定，结果显示，20例患者的临床和细菌学结果令人满意，2例不满意，1例结果存疑。1例患者发生致命性继发感染，可能与先前使用米诺环素治疗有关。未观察到毒性反应或副作用。
