促红细胞生成素对腹膜透析无肾大鼠贫血的影响。

Effect of erythropoietin on anemia of peritoneally dialyzed anephric rats.

作者信息

Van Stone J C, Max P

出版信息

Kidney Int. 1979 Apr;15(4):370-5. doi: 10.1038/ki.1979.48.

DOI:10.1038/ki.1979.48

Abstract

The effect of erythropoietin on anemia was studied in anephric rats undergoing peritoneal dialysis. Both the number of bone marrow red cell precursors and plasma iron turnover were markedly depressed in untreated peritoneally dialyzed anephric animals when compared to peritoneally dialyzed sham-operated control rats. Anephric rats receiving 2 U of erythropoietin per day for 12 days had greater than threefold more bone marrow red cell precursors and a twofold larger plasma iron turnover than did the saline injected anephric rats. There was no significant difference in either bone marrow red cell precursors or plasma iron turnover in the erythropoietin-treated anephric rats when compared to the nonuremic controls. Although the rats receiving erythropoietin for 12 days had a significantly higher hematocrit (29.5%) than the saline injected uremic rats did (19.0%), the hematocrit was significantly lower than that found in nonuremic control animals, either receiving erythropoietin (48.1%) or not receiving erythropoietin (41.6%). Our data suggests that erythropoietin is potentially a useful agent for the treatment of anemia of chronic renal failure.

摘要

在接受腹膜透析的无肾大鼠中研究了促红细胞生成素对贫血的影响。与接受腹膜透析的假手术对照大鼠相比，未经治疗的腹膜透析无肾动物的骨髓红细胞前体细胞数量和血浆铁周转率均显著降低。每天接受2单位促红细胞生成素治疗12天的无肾大鼠，其骨髓红细胞前体细胞数量比注射生理盐水的无肾大鼠多三倍以上，血浆铁周转率比后者大一倍。与非尿毒症对照组相比，接受促红细胞生成素治疗的无肾大鼠的骨髓红细胞前体细胞数量或血浆铁周转率均无显著差异。尽管接受促红细胞生成素治疗12天的大鼠的血细胞比容（29.5%）显著高于注射生理盐水的尿毒症大鼠（19.0%），但其血细胞比容仍显著低于未接受促红细胞生成素治疗（41.6%）或接受促红细胞生成素治疗（48.1%）的非尿毒症对照动物。我们的数据表明，促红细胞生成素可能是治疗慢性肾衰竭贫血的有效药物。