正常和卟啉症大鼠脑、心脏、肾脏和肝脏中的亚铁螯合酶和δ-氨基乙酰丙酸合成酶。烯丙基异丙基乙酰胺对肾脏胞质溶胶和线粒体中δ-氨基乙酰丙酸合成酶的诱导作用。
Ferrochelatase and -aminolaevulate synthetase in brain, heart, kidney and liver of normal and porphyric rats. The induction of -aminolaevulate synthetase in kidney cytosol and mitochondria by allylisopropylacetamide.
作者信息
Barnes R, Jones M S, Jones O T, Porra R J
出版信息
Biochem J. 1971 Sep;124(3):633-7. doi: 10.1042/bj1240633.
Abstract
- delta-Aminolaevulate synthetase was detected in liver and kidney mitochondria prepared from normal rats. 2. The administration of allylisopropylacetamide induced an increase in delta-aminolaevulate synthetase in both liver and kidney mitochondria and the enzyme also appeared in the cytosol fraction of both tissues. Comparison with the distribution of glutamate dehydrogenase indicated that this soluble kidney delta-aminolaevulate synthetase was truly of cytosol origin and did not arise from disrupted mitochondria. The kidney cytosol enzyme was inhibited by 50% by 50mum-protohaem. 3. delta-Aminolaevulate synthetase could not be detected in mitochondria or cytosol from heart or brain from normal or porphyric rats. 4. The administration of allylisopropylacetamide caused little or no increase in ferrochelatase or cytochrome content of liver, kidney, heart or brain mitochondria.
摘要
- 在从正常大鼠制备的肝和肾线粒体中检测到δ-氨基乙酰丙酸合成酶。2. 给予烯丙基异丙基乙酰胺后，肝和肾线粒体中的δ-氨基乙酰丙酸合成酶均增加，并且该酶也出现在两个组织的胞质部分。与谷氨酸脱氢酶的分布比较表明，这种可溶性肾δ-氨基乙酰丙酸合成酶确实起源于胞质，并非来自受损的线粒体。肾胞质酶被50μM原卟啉抑制50%。3. 在正常或卟啉症大鼠的心脏或脑的线粒体或胞质中未检测到δ-氨基乙酰丙酸合成酶。4. 给予烯丙基异丙基乙酰胺后，肝、肾、心脏或脑线粒体的铁螯合酶或细胞色素含量几乎没有增加或没有增加。
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本文引用的文献
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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Studies on the induction of hepatic delta-aminolevulinic acid synthetase in rat liver mitochondria.大鼠肝脏线粒体中肝δ-氨基乙酰丙酸合成酶诱导作用的研究。
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