巴比妥类药物的胆汁排泄。
Biliary excretion of barbiturates.
作者信息
Klaassen C D
出版信息
Br J Pharmacol. 1971 Sep;43(1):161-6. doi: 10.1111/j.1476-5381.1971.tb07165.x.
Abstract
- Pentobarbitone and phenobarbitone are excreted into the bile of rats.2. The concentration of pentobarbitone and/or its metabolites in the bile is 22-fold higher than in the plasma; the concentration of phenobarbitone and/or its metabolites in bile is 10-fold higher than in the plasma.3. Probenecid decreases the excretion of the barbiturates into the bile.4. Twenty-eight per cent of a 35 mg/kg dose of pentobarbitone and 18% of a 75 mg/kg dose of phenobarbitone is excreted in the bile in 6 hours.5. Most of the pentobarbitone and phenobarbitone excreted into the bile is not in the form of the parent compound but rather as a more polar metabolite or metabolites.
摘要
戊巴比妥和苯巴比妥会排泄到大鼠胆汁中。
胆汁中戊巴比妥及其代谢物的浓度比血浆中高22倍；胆汁中苯巴比妥及其代谢物的浓度比血浆中高10倍。
丙磺舒会减少巴比妥类药物向胆汁中的排泄。
35mg/kg剂量的戊巴比妥中有28%以及75mg/kg剂量的苯巴比妥中有18%在6小时内排泄到胆汁中。
排泄到胆汁中的大部分戊巴比妥和苯巴比妥不是以母体化合物的形式，而是以一种或多种极性更强的代谢物的形式存在。
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Plasma levels and urinary excretion of three barbituric acids after oral administration to man.
Acta Pharmacol Toxicol (Copenh). 1954;10(2):147-65. doi: 10.1111/j.1600-0773.1954.tb01332.x.
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J Pharmacol Exp Ther. 1954 Aug;111(4):425-35.
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