乙醇与吡唑在实验啮齿动物中的相互作用效应。
Interaction effects of ethanol and pyrazole in laboratory rodents.
作者信息
Blum K, Geller I, Wallace J E
出版信息
Br J Pharmacol. 1971 Sep;43(1):67-73. doi: 10.1111/j.1476-5381.1971.tb07157.x.
Abstract
- Interactions of pyrazole and ethanol were studied in three laboratory test procedures. They included sleeping time in mice, rotor rod balance in rats and lever pressing behaviour of rats.2. Equimolar concentrations of pyrazole and 3-methylpyrazole were compared for effects on enhancement of ethanol's activity on rotor rod holding time of rats.3. Minimally effective doses of pyrazole, the LADH inhibitor, and 3-methylpyrazole, a non-inhibitor of LADH, when administered before ethanol, resulted in an increased behavioural depression. These interaction effects are probably not caused by inhibition of LADH but rather by an increase in the direct depressant action of either one or both of the compounds.
摘要
在三种实验室测试程序中研究了吡唑与乙醇的相互作用。这些程序包括小鼠的睡眠时间、大鼠的转棒平衡能力以及大鼠的压杆行为。
比较了等摩尔浓度的吡唑和3-甲基吡唑对增强乙醇对大鼠转棒保持时间影响的作用。
在乙醇给药前给予最低有效剂量的吡唑（一种醇脱氢酶抑制剂）和3-甲基吡唑（一种非醇脱氢酶抑制剂），会导致行为抑制增强。这些相互作用效应可能不是由醇脱氢酶抑制引起的，而是由这两种化合物中一种或两种的直接抑制作用增强所致。
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