吡唑（一种乙醇脱氢酶抑制剂）对大鼠乙醇产前毒性的影响。
Influence of pyrazole, an inhibitor of alcohol dehydrogenase on the prenatal toxicity of ethanol in the rat.
作者信息
Varma P K, Persaud T V
出版信息
Res Commun Chem Pathol Pharmacol. 1979 Oct;26(1):65-73.
PMID:515510
Abstract
Pyrazole, a potent inhibitor of alcohol dehydrogenase, induced a high incidence of ocular and urinary bladder anomalies in the offspring of rats following treatment on gestational day 9. A single moderate dose of ethanol potentiated the teratogenic action of pyrazole, but alone did not affect embryonic development.
摘要
吡唑是一种有效的乙醇脱氢酶抑制剂，在妊娠第9天对大鼠进行治疗后，其后代出现眼部和膀胱异常的发生率很高。单次中等剂量的乙醇可增强吡唑的致畸作用，但单独使用乙醇不会影响胚胎发育。
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