Identification of the chemical groups involved in the binding of periodate-oxidized NADP+ to 6-phosphogluconate dehydrogenase.
作者信息
Dallocchio F, Negrini R, Signorini M, Rippa M
出版信息
Biochim Biophys Acta. 1976 May 13;429(3):629-34. doi: 10.1016/0005-2744(76)90312-0.
PMID:5137
Abstract
Periodate-oxidized NADP+ binds specifically and reversibly to the NADP+ binding site of 6-phosphogluconate dehydrogenase (EC 1.1.1.44) from Candida utilis. The inhibition can be stabilized by reduction with sodium borohydride. It has been shown that an aldehydic group of the inhibitor forms a Schiff base with a lysine residue of the enzyme.
摘要
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