Gibbs N M, French L W
J Clin Pathol. 1971 Dec;24(9):867-9. doi: 10.1136/jcp.24.9.867.
One thousand one hundred and thirty sera from hospital patients under investigation for autoimmune disease were tested for colon mucus antibody and tissue antibodies. The sera with a positive mucus antibody were retested against a panel of test colons of known blood group using IgG, IgA, and IgM antihuman globulin fluorescein isothiocyanate conjugate. It was found that there was a variation between the results obtained with different test colons. This was considered to be due to a system in tissues of mucus isoantigens produced by the goblet cells of the colon. Using this panel of test colons raised the percentage of mucus antibodies detected in cases of ulcerative colitis from 14 to 37%. The presence of the mucus antibody was found to be shortlived in some patients. The colon mucus antibody was also found in thyroid disease and chronic asthma and the reasons for this finding are discussed.
对1130份来自因自身免疫性疾病接受调查的住院患者的血清进行了结肠黏液抗体和组织抗体检测。对黏液抗体呈阳性的血清，使用IgG、IgA和IgM抗人球蛋白异硫氰酸荧光素共轭物，针对一组已知血型的测试结肠进行重新检测。发现使用不同的测试结肠获得的结果存在差异。这被认为是由于结肠杯状细胞产生的黏液同种抗原在组织中的一种系统所致。使用这组测试结肠，溃疡性结肠炎病例中检测到的黏液抗体百分比从14%提高到了37%。发现一些患者体内的黏液抗体存在时间较短。在甲状腺疾病和慢性哮喘患者中也发现了结肠黏液抗体，并对这一发现的原因进行了讨论。
