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致命性硫利达嗪心脏毒性。

Fatal thioridazine cardiotoxicity.

作者信息

Burgess K R, Jefferis R W, Stevenson I F

出版信息

Med J Aust. 1979 Aug 25;2(4):177-8. doi: 10.5694/j.1326-5377.1979.tb142025.x.

DOI:10.5694/j.1326-5377.1979.tb142025.x
PMID:514124
Abstract

A case of fatal cardiotoxicity after a deliberate ingestion of 5000 mg thioridazine (Melleril) is reported. The serum thioridazine level is documented for the first time at the time of arrhythmia. Correct treatment of similar cases should often include insertion of a transvenous pacing wire, as the arrhythmias are generally resistant to drug therapy.

摘要

报告了一例故意摄入5000毫克硫利达嗪(美立廉)后发生致命心脏毒性的病例。在心律失常发生时首次记录了血清硫利达嗪水平。对于类似病例的正确治疗通常应包括插入经静脉起搏导线,因为心律失常通常对药物治疗有抵抗性。

相似文献

1
Fatal thioridazine cardiotoxicity.致命性硫利达嗪心脏毒性。
Med J Aust. 1979 Aug 25;2(4):177-8. doi: 10.5694/j.1326-5377.1979.tb142025.x.
2
Complete heart block and torsade de pointes associated with thioridazine poisoning.与硫利达嗪中毒相关的完全性心脏传导阻滞和尖端扭转型室性心动过速。
Pharmacotherapy. 1994 Mar-Apr;14(2):239-45.
3
Successful suicides with thioridazine and mesoridazine: a result of probable cardiotoxicity.使用硫利达嗪和甲砜达嗪导致的成功自杀案例:可能是心脏毒性的结果。
Arch Gen Psychiatry. 1977 Aug;34(8):955-7. doi: 10.1001/archpsyc.1977.01770200093012.
4
About a non-fatal massive intoxication with sustained-release thioridazine. Clinical and therapeutic problems.关于一例硫利达嗪缓释制剂非致命性大量中毒。临床及治疗问题。
Acta Pharmacol Toxicol (Copenh). 1977;41 Suppl 2:153-62.
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[Ventricular arrhythmia following thioridazine poisoning].[硫利达嗪中毒后室性心律失常]
Ann Cardiol Angeiol (Paris). 1991 Apr;40(4):199-201.
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Transient cardiac pacing is insufficiently used to treat arrhythmia associated with thioridazine.
Cardiology. 1992;81(6):340-1. doi: 10.1159/000175827.
7
Life-threatening dysrhythmias in severe thioridazine poisoning treated with physostigmine and transient atrial pacing.
Crit Care Med. 1997 Nov;25(11):1925-30. doi: 10.1097/00003246-199711000-00036.
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Control of recurrent ventricular fibrillation by transvenous pacing in the absence of heart block.在无心脏传导阻滞的情况下经静脉起搏控制复发性心室颤动
Am Heart J. 1967 Jun;73(6):794-7. doi: 10.1016/0002-8703(67)90230-x.
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Electrocardiographic abnormalities induced by thioridazine (Mellaril).
Am Heart J. 1968 Aug;76(2):153-6. doi: 10.1016/0002-8703(68)90189-0.
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Standby pacing in multiple arrhythmias.多种心律失常时的备用起搏
Isr J Med Sci. 1967 Mar-Apr;3(2):221-9.

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A case of risperidone overdose in early schizophrenia: a review of potential complications.一例早期精神分裂症患者利培酮过量:潜在并发症综述
J Psychiatry Neurosci. 1998 Nov;23(5):305-8.
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The biotransformation of thioridazine to thioridazine 5-sulfoxide stereoisomers in phenobarbital induced rats.
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