Lee I P, Suzuki K
Mutat Res. 1979 Oct;68(2):169-73. doi: 10.1016/0165-1218(79)90145-9.
Acute toxicity studies of 1,2-dibromo-3-chloropropane (DBCP) in mice demonstrated that the respective LD50 values for prepubertal and adult male mice were 180.7 mg/kg (154.0-197.5 mg/kg body weight) and 123 mg/kg (100.5-141.5 mg/kg body weight) which were significantly different. The slopes of the dose-response curves (1.2) were steep and essentially the same, indicating a narrow margin of safety. A single maximally tolerated dose of DBCP (100 mg/kg) administered intraperitoneally to prepubertal male mice induced significant unscheduled DNA synthesis in the premeiotic germ cells but not in spermatozoa.
对小鼠进行的1,2 - 二溴 - 3 - 氯丙烷（DBCP）急性毒性研究表明，青春期前雄性小鼠和成年雄性小鼠的半数致死量（LD50）分别为180.7毫克/千克（体重154.0 - 197.5毫克/千克）和123毫克/千克（体重100.5 - 141.5毫克/千克），二者存在显著差异。剂量 - 反应曲线的斜率（1.2）较陡且基本相同，表明安全范围较窄。对青春期前雄性小鼠腹腔注射一次最大耐受剂量的DBCP（100毫克/千克），可诱导减数分裂前生殖细胞中出现显著的非程序性DNA合成，但精子中未出现。
