肾内前列腺素：钠和消炎痛对兔前列腺素E2和前列腺素F2α的影响

Intrarenal prostaglandins: effect of sodium and indomethacin on PGE2 and PGF2 alpha in rabbits.

作者信息

Tsuruta K, Iihoshi M, Soejima H, Ikegami K

出版信息

Nephron. 1979;24(6):283-6. doi: 10.1159/000181737.

Abstract

The levels of prostaglandins (PGs) E2 and F2 alpha in different parts of the rabbit kidney were determined to observe the effect of sodium and indomethacin. After the pretreatment with injections of saline or with indomethacin, tissues from inner and outer medulla and cortex were separated, extracted, analyzed for PGE2 and PGF2 alpha by radioimmunoassay. In the normal rabbit kidney, the greatest amount of PG was found in the inner medulla. Saline injections appeared to increase PGE2 (but not PGF2 alpha), especially in the inner medulla. Repeated injections of saline, on the other hand, markedly reduced PGE2 in the inner medulla but increased outer medullary PGE2. Indomethacin reduced the production of PGs in all kidney segments. These results suggest the bidirectional effect of sodium on PG concentration in the rabbit kidney. Acute administration of sodium may directly stimulate the synthesis of PGE2 in the inner medulla but chronic stimulation with sodium may alter the pattern of PGE2 synthesis.

摘要

测定了兔肾不同部位前列腺素（PGs）E2和F2α的水平，以观察钠和吲哚美辛的作用。在注射生理盐水或吲哚美辛进行预处理后，分离出肾内髓质、外髓质和皮质的组织，进行提取，并通过放射免疫分析法检测PGE2和PGF2α。在正常兔肾中，PG含量最高的部位是内髓质。注射生理盐水似乎会增加PGE2（但不会增加PGF2α），尤其是在内髓质。另一方面，反复注射生理盐水会显著降低内髓质中的PGE2，但会增加外髓质中的PGE2。吲哚美辛会降低所有肾段中PGs的产生。这些结果表明钠对兔肾中PG浓度具有双向作用。急性给予钠可能直接刺激内髓质中PGE2的合成，但长期用钠刺激可能会改变PGE2的合成模式。