肾内前列腺素的研究。单侧输尿管梗阻对兔肾前列腺素E2和F2α的影响。

Studies on intraarenal prostaglandins. Influence of unilateral ureteral obstruction on prostaglandins E2 and F2 alpha in the rabbit kidney.

作者信息

Iihoshi M, Tsuruta K, Soejima H, Ikegami K

出版信息

Urol Int. 1979;34(6):430-9. doi: 10.1159/000280293.

Abstract

Prostaglandins (PGs) E2 and F2 alpha in the rabbit kidney were determined by radioimmunoassay to study the effects of unilateral ureteral obstruction on intrarenal PGs. An increase of PGE2 in the inner medulla was observed in the hydronephrotic kidney. When isotonic glucose solution was infused after the release of ureteral obstruction, an elevation of PGE2 in the outer medulla occurred in the hydronephrotic kidney. Under water diuresis immediately following the release of obstruction, PGE2 in the inner medulla showed significant correlations to urinary flow rate, urinary osmolar concentration and free water clearance. The present study indicates that PGE2 in the inner medulla is enhanced by ureteral obstruction and may have a close relation to renal functional damage in mild hydronephrosis.

摘要

通过放射免疫分析法测定了兔肾中的前列腺素（PGs）E2和F2α，以研究单侧输尿管梗阻对肾内PGs的影响。在肾积水的肾脏中，观察到内髓质中PGE2增加。在解除输尿管梗阻后输注等渗葡萄糖溶液时，肾积水肾脏的外髓质中PGE2升高。在梗阻解除后立即进行水利尿时，内髓质中的PGE2与尿流率、尿渗透压浓度和自由水清除率呈显著相关。本研究表明，输尿管梗阻可增强内髓质中的PGE2，且其可能与轻度肾积水时的肾功能损害密切相关。