Rolland P H, Martin P M, Rolland A M, Bourry M, Serment H
Obstet Gynecol. 1979 Dec;54(6):715-8.
Plasma levels of estradiol (E2), prostaglandin (PG)E2, and progesterone (P) were measured in both phases of the menstrual cycle in 22 women with benign mastopathies and in 5 normal women. In both phases of the cycle, PGE2 blood levels were significantly higher in patients with benign mastopathies than in normal women. In contrast, the plasma levels of both steroids were lower in patients than in controls. An estrogen-directed synthesis of PGE2 is proposed. In 10 patients, breast thermogenic response to inhibitors of PG biosynthesis (aspirin and indomethacin) revealed a cooling effect in 4 cases, a partly positive response in 3 cases, and no response in 3 cases. The 7 cases with positive responses also had a deficiency of variable magnitude of both steroids without an unbalanced P/E2 ratio. In contrast, patients with a negative thermographic response manifested very low levels of progesterone and a low P/E2 ratio. The significance of patients' unresponsiveness to inhibitors of PGE2 biosynthesis is discussed, as well as the implications with regard to breast cancer.
对22例患有良性乳腺病的女性和5例正常女性在月经周期的两个阶段均检测了雌二醇（E2）、前列腺素（PG）E2和孕酮（P）的血浆水平。在月经周期的两个阶段，患有良性乳腺病的患者血液中PGE2水平均显著高于正常女性。相比之下，患者体内两种类固醇的血浆水平均低于对照组。提出了雌激素导向的PGE2合成。在10例患者中，乳房对PG生物合成抑制剂（阿司匹林和吲哚美辛）的产热反应显示，4例有降温作用，3例有部分阳性反应，3例无反应。7例有阳性反应的患者同时也存在不同程度的两种类固醇缺乏，但P/E2比值无失衡。相比之下，热成像反应阴性的患者孕酮水平极低，P/E2比值也很低。讨论了患者对PGE2生物合成抑制剂无反应的意义，以及与乳腺癌的关系。
