Rolland P H, Martin P M, Bourry M, Serment H
J Gynecol Obstet Biol Reprod (Paris). 1981;10(3):197-201.
During both phases of their menstrual cycle, women who suffer from benign mastopathies evidence hormonal deficiency, which is total although of variable magnitude, as shown by oestradiol (E2) and progesterone (p) plasma levels. by contrast, these women show a concomitant and large rise of prostaglandin E2 (PGE2) plasma level. An oestrogen directed PGE2 synthesis by the mammary epithelium is likely to occur. The patients whose mammary thermography displays PG synthesis can be cooled by the administration of PG synthesis inhibitors. They show a steroid deficiency which is more or less pronounced without having any marked imbalance of the E2-P ratio. By contrast, patients who exhibit no thermographic response show a marked relative rise in oestrogen during both phases of the menstrual cycle. The significance of PG synthesis and relatively raised oestrogen levels will be discussed in relationship to the risk of breast cancer.
在月经周期的两个阶段，患有良性乳腺病的女性都存在激素缺乏，尽管程度不同但这种缺乏是全面的，这由雌二醇（E2）和孕酮（p）的血浆水平得以体现。相比之下，这些女性的血浆前列腺素E2（PGE2）水平会同时大幅升高。乳腺上皮细胞可能发生雌激素导向的PGE2合成。乳腺热成像显示有PG合成的患者，通过服用PG合成抑制剂可使其体温降低。他们表现出程度不一的类固醇缺乏，且E2 - P比值无明显失衡。相比之下，热成像无反应的患者在月经周期的两个阶段雌激素均有明显相对升高。将结合乳腺癌风险来讨论PG合成及雌激素水平相对升高的意义。
