拉贝洛尔所致左心室衰竭
Left ventricular failure with labetalol.
作者信息
Frais M A, Bayley T J
出版信息
Postgrad Med J. 1979 Sep;55(646):567-8. doi: 10.1136/pgmj.55.646.567.
Abstract
A patient treated for hypertension with labetalol developed left ventricular failure. When the drug was withdrawn and the BP controlled with 2 other agents, the signs of heart failure regressed. The ill effects in this case could have been because the beta-blocking effects of labetalol are 4 to 6 times greater than the alpha-blocking effects. Caution should be exercised when prescribing this drug for patients with heart failure or with previous symptoms.
摘要
一名使用拉贝洛尔治疗高血压的患者出现了左心室衰竭。当停用该药物并用其他两种药物控制血压时，心力衰竭的症状消退。该病例中的不良影响可能是因为拉贝洛尔的β受体阻滞作用比α受体阻滞作用大4至6倍。为心力衰竭患者或有既往症状的患者开此药时应谨慎。
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引用本文的文献
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Drugs. 1984;28 Suppl 2:51-68. doi: 10.2165/00003495-198400282-00005.
本文引用的文献
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The effects of oral AH 5158, a combined α and β-adrenoceptor antagonist, in healthy volunteers.口服 AH5158（一种联合的α和β肾上腺素能受体拮抗剂）在健康志愿者中的作用。
Br J Clin Pharmacol. 1974 Dec;1(6):505-10. doi: 10.1111/j.1365-2125.1974.tb01702.x.
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Haemodynamic effects of long-term oral labetalol.长期口服拉贝洛尔的血流动力学效应。
Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):733-6.
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Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):681-4.
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