甲氨蝶呤耐药性发展过程中白血病L1210的二氢叶酸还原酶活性 - Suppr | 超能文献

Dihydrofolate reductase activity of leukemia L1210 during development of methotrexate resistance.

作者信息

Schrecker A W, Mead J A, Greenberg N H, Goldin A

出版信息

Biochem Pharmacol. 1971 Mar;20(3):716-8. doi: 10.1016/0006-2952(71)90159-6.

DOI:10.1016/0006-2952(71)90159-6

Abstract

摘要

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Dihydrofolate reductase activity of leukemia L1210 during development of methotrexate resistance.甲氨蝶呤耐药性发展过程中白血病L1210的二氢叶酸还原酶活性

Biochem Pharmacol. 1971 Mar;20(3):716-8. doi: 10.1016/0006-2952(71)90159-6.

2

Immunologic heterogeneity of dihydrofolate reductase from methotrexate sensitive and resistant L1210 leukemia cells.来自甲氨蝶呤敏感和耐药L1210白血病细胞的二氢叶酸还原酶的免疫异质性。

Proc Soc Exp Biol Med. 1985 Oct;180(1):98-102. doi: 10.3181/00379727-180-42149.

3

Dihydrofolate reductase activity and loss of resistance in an antifolate-resistant subline of leukemia L1210 after discontinuation of treatment.白血病L1210抗叶酸耐药亚系在停药后二氢叶酸还原酶活性及耐药性丧失

Chem Biol Interact. 1970 Oct;2(3):229-34. doi: 10.1016/0009-2797(70)90025-6.

4

Limited effectiveness of in vitro high-dose methotrexate and leucovorin to overcome resistance in L1210 leukemia cells with elevations of dihydrofolate reductase.体外高剂量甲氨蝶呤和亚叶酸钙克服二氢叶酸还原酶升高的L1210白血病细胞耐药性的效果有限。

Eur J Cancer (1965). 1980 Aug;16(8):1057-63. doi: 10.1016/0014-2964(80)90253-4.

5

Substrate and inhibitor complexes of dihydrofolate reductase from amethopterin-resistant L1210 cells.来自氨甲蝶呤抗性L1210细胞的二氢叶酸还原酶的底物和抑制剂复合物

Arch Biochem Biophys. 1975 Dec;171(2):435-43. doi: 10.1016/0003-9861(75)90052-1.

6

Multiple forms of L1210 dihydrofolate reductase differing in affinity for methotrexate.对甲氨蝶呤亲和力不同的多种形式的L1210二氢叶酸还原酶。

Biochem Biophys Res Commun. 1984 Feb 29;119(1):352-8. doi: 10.1016/0006-291x(84)91658-9.

7

A new fluorescent dihydrofolate reductase probe for studies of methotrexate resistance.一种用于研究甲氨蝶呤耐药性的新型荧光二氢叶酸还原酶探针。

J Biol Chem. 1982 Dec 10;257(23):14162-7.

8

Dihydrofolate reductase from a resistant subline of the L1210 lymphoma. Purification by affinity chromatography and ultraviolet difference spectrophotometric and circular dichroic studies.来自L1210淋巴瘤耐药亚系的二氢叶酸还原酶。通过亲和层析法进行纯化以及紫外差示分光光度法和圆二色性研究。

Biochemistry. 1977 Jul 12;16(14):3073-9. doi: 10.1021/bi00633a005.

9

Antifolate polyglutamylation and competitive drug displacement at dihydrofolate reductase as important elements in leucovorin rescue in L1210 cells.抗叶酸聚谷氨酸化及二氢叶酸还原酶处的竞争性药物置换作为L1210细胞中亚叶酸解救的重要因素。

Cancer Res. 1986 Feb;46(2):588-93.

10

Amethopterin-induced changes in the multiple forms of dihydrofolate reductase from L1210 cells.

Arch Biochem Biophys. 1970 Mar;137(1):295-6. doi: 10.1016/0003-9861(70)90440-6.

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Dipyridamole inhibits reversion by thymidine of methotrexate effect and increases drug uptake in Sarcoma 180 cells.双嘧达莫可抑制甲氨蝶呤作用的胸腺嘧啶核苷逆转，并增加肉瘤180细胞对药物的摄取。

Proc Natl Acad Sci U S A. 1984 May;81(10):3200-3. doi: 10.1073/pnas.81.10.3200.