一名12岁女孩患伴有胰岛素抵抗的非酮症高渗性昏迷。
Non-ketotic hyperosmolar coma with insulin resistance in a 12-year-old girl.
作者信息
Dagnone L E, Reid J D, Green R N
出版信息
Can Med Assoc J. 1971 Nov;105(9):940 passim.
Although the frequency of recognition of the syndrome of non-ketotic hyperosmolar coma is increasing in all age groups the mortality rate remains high. This paper reports the occurrence of this syndrome in a 12-year-old girl. The pathogenesis is discussed and a planned approach to the management of circulatory collapse, hypokalemia, hyperglycemia and hyperosmolarity over the initial 24 hours is proposed. The phenomenon of insulin resistance which was observed in this case is a rare complication of this syndrome. Awareness of the occurrence of this syndrome in all age groups, early recognition of its features and a planned approach to management are mandatory to reduce the very high mortality rate.
尽管非酮症高渗性昏迷综合征在各年龄组中的确诊率都在上升，但其死亡率仍然很高。本文报告了一名12岁女孩患该综合征的病例。文中讨论了其发病机制，并提出了在最初24小时内针对循环衰竭、低钾血症、高血糖和高渗状态的计划性处理方法。该病例中观察到的胰岛素抵抗现象是此综合征罕见的并发症。认识到该综合征在各年龄组中的发生情况、早期识别其特征以及采取计划性的处理方法对于降低极高的死亡率至关重要。
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