Leung P M, Rogers Q R
Physiol Behav. 1979 Jul;23(1):129-36. doi: 10.1016/0031-9384(79)90132-x.
Bilateral double electrolytic overlapping lesions were placed in dorsal-lateral hippocampus of male 230 g rats, and their food intake responses to the ingestion of diets containing disproportionate amounts of amino acids were examined. Rats with such lesions and intact control rats maintained their normal intakes of the 6% casein basal diet or a threonine basal amino acid diet postoperatively. However, they exhibited marked initial food intake depression, similar to that of intact rats, when fed the threonine imbalanced amino acid diet. Also, animals with lesions in certain areas of the dorsal-lateral hippocampus showed facilitated adaptation to the amino acid imbalanced diet. Similar severe reduction in food intake with relative lack of adaptation were observed in both the intact controls and rats with hippocampal lesions when fed amino acid diets completely devoid of threonine. Initial food intake of rats with hippocampal lesions was inhibited drastically as was the case with the intact controls when fed a 75% casein high protein diet. All rats, either intact or lesioned, showed similar slow adaptation patterns with the prolonged ingestion of the high protein diet. The initial food intake responses and facilitated adaptation of the animals bearing lesions in certain areas of the hippocampus suggest that such areas are not crucially involved in the inhibition of food intake of rats fed disproportionate amounts of dietary amino acids. Rather, such areas of lesions in the hippocampus may play a role in a system governing the behavioral adaptation of the intake of amino acid imbalanced diets but not of diets containing amino acids in general excess. This would also indicate that different mechanisms control the intake of amino acid imbalanced diets and diets containing amino acids in excess.
在230克雄性大鼠的背外侧海马区植入双侧双电解重叠损伤，并检测它们对摄入含不同比例氨基酸饮食的食物摄入反应。有此类损伤的大鼠和完整对照大鼠术后维持其对6%酪蛋白基础饮食或苏氨酸基础氨基酸饮食的正常摄入量。然而，当给它们喂食苏氨酸失衡氨基酸饮食时，它们表现出明显的初始食物摄入量下降，这与完整大鼠相似。此外，背外侧海马区某些区域有损伤的动物对氨基酸失衡饮食表现出适应性增强。当给完整对照大鼠和海马损伤大鼠喂食完全不含苏氨酸的氨基酸饮食时，观察到类似的严重食物摄入量减少且相对缺乏适应性。当给海马损伤大鼠喂食75%酪蛋白高蛋白饮食时，其初始食物摄入量像完整对照大鼠一样受到极大抑制。所有大鼠，无论是完整的还是有损伤的，在长期摄入高蛋白饮食时都表现出相似的缓慢适应模式。海马区某些区域有损伤的动物的初始食物摄入反应和适应性增强表明，这些区域在抑制摄入含不同比例膳食氨基酸的大鼠的食物摄入方面并非至关重要。相反，海马区的此类损伤区域可能在一个控制系统中发挥作用，该系统控制对氨基酸失衡饮食而非一般过量含氨基酸饮食摄入的行为适应。这也表明不同的机制控制氨基酸失衡饮食和过量含氨基酸饮食的摄入。
