Meliza L L, Leung P M, Rogers Q R
Physiol Behav. 1983 Feb;30(2):243-6. doi: 10.1016/0031-9384(83)90013-6.
The effect of anterior cingulate cortex lesions on dietary intake and adaptation of disproportionate amounts of amino acids was examined. Rats with bilateral electrolytic lesions in the anterior cingulate cortex and sham-operated rats were fed, in turn, amino acid basal, imbalanced or devoid diets involving threonine and isoleucine as the growth limiting amino acids, and then a low protein (6% casein) followed by a high protein (75% casein) diet. Lesions of the anterior cingulate cortex did not prevent the initial depression in food intake of the amino acid imbalanced diets, but shortened the duration of anorexia associated with dietary amino acid imbalances. Cingulate lesions did not influence the food intake of rats fed amino acid devoid diets. When switched from a low protein to a high protein diet, animals bearing lesions and sham-operated controls reduced markedly their initial food intake and adapted to the high protein diet in similar manner. It was concluded that the initial food intake depression associated with a dietary amino acid imbalance is a direct response to postingestive cues which influence food intake. Moreover, that the difference in adaptive intakes of the cingulate cortex lesioned animals who ingested a diet of imbalanced amino acids or of high protein, indicates that separate mechanisms act to control food intake of animals fed diets containing imbalanced amino acid mixtures or diets with excessive amounts of protein.
研究了前扣带皮层损伤对饮食摄入以及不均衡氨基酸适应情况的影响。依次给前扣带皮层有双侧电解损伤的大鼠和假手术大鼠喂食以苏氨酸和异亮氨酸作为生长限制氨基酸的氨基酸基础日粮、不均衡日粮或无氨基酸日粮，然后是低蛋白（6%酪蛋白）日粮，接着是高蛋白（75%酪蛋白）日粮。前扣带皮层损伤并未阻止氨基酸不均衡日粮导致的最初食物摄入量下降，但缩短了与日粮氨基酸不均衡相关的厌食持续时间。扣带损伤不影响喂食无氨基酸日粮大鼠的食物摄入量。当从低蛋白日粮转换为高蛋白日粮时，有损伤的动物和假手术对照组的动物均显著降低了最初的食物摄入量，并以相似的方式适应了高蛋白日粮。得出的结论是，与日粮氨基酸不均衡相关的最初食物摄入量下降是对影响食物摄入的摄食后线索的直接反应。此外，摄入不均衡氨基酸日粮或高蛋白日粮的扣带皮层损伤动物在适应性摄入量上的差异表明，存在不同的机制来控制喂食含不均衡氨基酸混合物日粮或高蛋白日粮动物的食物摄入。
