胆汁酸溶液胆总管灌注对Oddi括约肌活性的影响（作者译）

[Effects of choledochal perfusion with biliary acid solutions on activity of the sphincter of Oddi (author's transl)].

作者信息

Bevilacqua R G, Margarido N F, Soares L A, Mansur R, Koch V, Gonçalves E L

出版信息

Rev Bras Pesqui Med Biol. 1979 Jun;12(2-3):177-83.

Abstract

The changes of sphincter of Oddi's resistance, induced by choledochal perfusion of conjugated (taurocolic) and non-conjugated (colic) biliary acid solutions, in anesthetized dogs, were studied. The perfusions were made at a constant flow and intracholedochal pressures were registered. The mean number of contractions per minute, the mean maximal pressures and the mean minimal pressures in each study periods were analysed. The choledochal perfusion with the biliary acids solutions induced a slight but significative increase in sphincteric resistance. After 15 minutes, the perfusion with colic acid solution induced maximal pressures significantly more elevated than the ones observed with taurocolic acid solution. The non-conjugated solution induced a pressure tracing significantly distinct from the tracing observed with the conjugated acid solution. No changes in resistance were observed with a 2% NaCl solution. This implies that the observed changes in resistance were not related to osmotic stimulation of the sphincter of Oddi.

摘要

研究了在麻醉犬中，通过胆总管灌注结合型（牛磺胆酸）和非结合型（胆酸）胆汁酸溶液诱导的Oddi括约肌阻力变化。以恒定流量进行灌注，并记录胆总管内压力。分析每个研究时段每分钟的平均收缩次数、平均最大压力和平均最小压力。用胆汁酸溶液进行胆总管灌注会使括约肌阻力轻微但显著增加。15分钟后，用胆酸溶液灌注诱导的最大压力明显高于用牛磺胆酸溶液观察到的最大压力。非结合型溶液诱导的压力曲线与结合型酸溶液观察到的曲线明显不同。用2%氯化钠溶液未观察到阻力变化。这意味着观察到的阻力变化与Oddi括约肌的渗透刺激无关。