巴比妥和双硫仑对大鼠脑室内注射[14C]-5-羟色胺代谢的影响。

Effects of barbital and disulfiram on the metabolism of intracerebroventricularly administered [14C]-5-hydroxytryptamine in rats.

作者信息

Fukumori R, Minegishi A, Satoh T, Kitagawa H, Yanaura S

出版信息

Res Commun Chem Pathol Pharmacol. 1979 Oct;26(1):217-20.

Abstract

Effects of barbital and disulfiram on the metabolism of serotonin (5-HT) in vivo were studied. One hr after intracerebroventricular injection of [14C]-5-HT (3 nmoles, 0.5 muCi), the levels of the total and deaminated radioactive materials were increased in rats receiving either barbital or disulfiram, as compared to those of control rats. In addition, an additive effect was observed by a combined administration of these two drugs. The results in this paper strongly suggest that barbital and disulfiram inhibit the metabolism of 5-hydroxyindoleacetaldehyde (5-HIAAld), a first deaminated metabolite in 5-HT metabolism.

摘要

研究了巴比妥和双硫仑对体内血清素（5-羟色胺，5-HT）代谢的影响。脑室内注射[14C]-5-HT（3纳摩尔，0.5微居里）1小时后，与对照大鼠相比，接受巴比妥或双硫仑的大鼠体内总放射性物质和脱氨基放射性物质的水平升高。此外，联合使用这两种药物观察到了相加作用。本文的结果有力地表明，巴比妥和双硫仑抑制5-羟色胺代谢中首个脱氨基代谢产物5-羟吲哚乙醛（5-HIAAld）的代谢。