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1
Mechanism of fat malabsorption in rats infected with Nippostrongylus brasiliensis.巴西日圆线虫感染大鼠脂肪吸收不良的机制
Gut. 1971 Dec;12(12):1007-10. doi: 10.1136/gut.12.12.1007.
2
Jejunal malabsorption in the rat infected by the nematode Nippostrongylus brasiliensis.
Int J Parasitol. 1971 Sep;1(2):179-87. doi: 10.1016/0020-7519(71)90013-0.
3
Fat malabsorption--advances in our understanding.
Am J Med. 1979 Dec;67(6):980-8. doi: 10.1016/0002-9343(79)90639-9.
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Normal mechanisms of fat absorption and derangements induced by various gastrointestinal diseases.
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Fat absorption in essential fatty acid deficiency: a model experimental approach to studies of the mechanism of fat malabsorption of unknown etiology.必需脂肪酸缺乏时的脂肪吸收：一种研究病因不明的脂肪吸收不良机制的模型实验方法。
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6
Fat malabsorption in cystic fibrosis patients receiving enzyme replacement therapy is due to impaired intestinal uptake of long-chain fatty acids.接受酶替代疗法的囊性纤维化患者出现脂肪吸收不良是由于长链脂肪酸的肠道吸收受损。
Am J Clin Nutr. 1999 Jan;69(1):127-34. doi: 10.1093/ajcn/69.1.127.
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Use of hydrogen gas (H2) analysis to assess intestinal absorption. Studies in normal rats and in rats infected with the nematode, Nippostrongylus brasiliensis.使用氢气（H2）分析评估肠道吸收。对正常大鼠和感染巴西日圆线虫的大鼠进行的研究。
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Fecal fat and nitrogen in healthy children and in children with malabsorption or maldigestion.健康儿童以及患有吸收不良或消化不良的儿童的粪便脂肪和氮含量。
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引用本文的文献

1
Mechanisms of lipid loss from the small intestinal mucosa.小肠黏膜脂质流失的机制。
Gut. 1975 Feb;16(2):118-124. doi: 10.1136/gut.16.2.118.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
KINETICS OF THE EPITHELIAL CELLS, AND MORPHOLOGY OF VILLI AND CRYPTS IN THE JEJUNUM OF THE RAT INFECTED BY THE NEMATODE NIPPOSTRONGYLUS BRASILIENSIS.感染巴西日圆线虫的大鼠空肠上皮细胞动力学及绒毛和隐窝形态学
Gastroenterology. 1965 Aug;49:158-68.
3
EFFECT OF INTESTINAL RESECTION ON BILE SALT ABSORPTION IN DOGS.肠切除对犬胆盐吸收的影响。
Am J Physiol. 1965 Feb;208:363-9. doi: 10.1152/ajplegacy.1965.208.2.363.
4
INTESTINAL ABSORPTION OF FATS.脂肪的肠道吸收
J Lipid Res. 1964 Oct;5:495-521.
5
STUDIES ON THE INTESTINAL ABSORPTION AND INTRAMUCOSAL LIPOLYSIS OF A MEDIUM CHAIN TRIGLYCERIDE.中链甘油三酯的肠道吸收及黏膜内脂肪分解研究
J Clin Invest. 1964 May;43(5):878-85. doi: 10.1172/JCI104973.
6
Biochemical pathology of the rat jejunum parasitized by the nematode nippostrongylus brasiliensis.被巴西日圆线虫寄生的大鼠空肠的生化病理学
Exp Parasitol. 1963 Jun;13:284-304. doi: 10.1016/0014-4894(63)90081-x.
7
Pathology, absorption, transport, and activity of digestive enzymes in rat jejunum parasitized by the nematode Nippostrongylus brasiliensis.感染巴西日圆线虫的大鼠空肠中消化酶的病理学、吸收、转运及活性研究
Fed Proc. 1962 Nov-Dec;21:913-8.
8
The esterification of palmitate-1-C14 by homogenates of intestinal mucosa.肠黏膜匀浆对棕榈酸-1-C14的酯化作用。
J Clin Invest. 1960 Jan;39(1):150-60. doi: 10.1172/JCI104014.
9
A morphologic and histochemical analysis of the human jejunal epithelium in nontropical sprue.非热带性口炎性腹泻患者空肠上皮的形态学与组织化学分析
Gastroenterology. 1961 Jun;40:735-65.
10
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.

巴西日圆线虫感染大鼠脂肪吸收不良的机制

Mechanism of fat malabsorption in rats infected with Nippostrongylus brasiliensis.

作者信息

Gallagher N D, Playoust M R, Symons L E

出版信息

Gut. 1971 Dec;12(12):1007-10. doi: 10.1136/gut.12.12.1007.

DOI:10.1136/gut.12.12.1007
PMID:5157129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1412000/
Abstract

Long-chain fatty acid absorption in rats with a jejunal lesion similar to that which is found in adult coeliac disease has been studied. Neither changes in the solubility of the fatty acid in the intestinal lumen nor histological abnormalities of the villous epithelium accounted for the malabsorptive state. Evidence was obtained from studies in vivo of a disturbance in the intramucosal esterification of long-chain fatty acid. Assay of the activity of the microsomal enzymes responsible for the conversion of fatty acid to triglyceride revealed that this pathway was defective in the parasitized animals.

摘要

对患有与成人乳糜泻中所见类似空肠病变的大鼠的长链脂肪酸吸收情况进行了研究。脂肪酸在肠腔内溶解度的变化以及绒毛上皮的组织学异常均不能解释吸收不良状态。通过体内研究获得证据，表明长链脂肪酸的黏膜内酯化过程存在紊乱。对负责将脂肪酸转化为甘油三酯的微粒体酶活性进行测定发现，该途径在患病动物中存在缺陷。