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Plasma concentrations of fenfluramine and its metabolite, norfenfluramine, after single and repeated oral administration.

作者信息

Campbell D B, Turner P

出版信息

Br J Pharmacol. 1971 Oct;43(2):465P-466P.

PMID:5158239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1665871/
Abstract
摘要

相似文献

1
Plasma concentrations of fenfluramine and its metabolite, norfenfluramine, after single and repeated oral administration.单次及重复口服给药后芬氟拉明及其代谢产物去甲芬氟拉明的血浆浓度。
Br J Pharmacol. 1971 Oct;43(2):465P-466P.
2
The measurement of d-fenfluramine and its metabolite, d-norfenfluramine in plasma and urine with an application of the method to pharmacokinetic studies.
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3
Enantioselective gas chromatographic assay with electron-capture detection for dl-fenfluramine and dl-norfenfluramine in plasma.血浆中右芬氟拉明和去甲右芬氟拉明的对映体选择性气相色谱-电子捕获检测法测定
J Chromatogr. 1988 Dec 9;433:105-17. doi: 10.1016/s0378-4347(00)80589-7.
4
Distribution of fenfluramine in normal and obese mice.芬氟拉明在正常小鼠和肥胖小鼠中的分布。
Int J Obes. 1978;2(1):1-5.
5
Pharmacokinetics of fenfluramine enantiomers in man.
Eur J Drug Metab Pharmacokinet. 1979;4(3):129-32. doi: 10.1007/BF03189414.
6
Gas chromatographic measurement of levels of fenfluramine and norfenfluramine in human plasma, red cells and urine following therapeutic doses.治疗剂量后人体血浆、红细胞和尿液中芬氟拉明和去甲芬氟拉明水平的气相色谱测定。
J Chromatogr. 1970 Jun 24;49(3):442-7. doi: 10.1016/s0021-9673(00)93657-4.
7
Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given D- and DL-fenfluramine for 15 days.给予D-和DL-芬氟拉明15天的志愿者体内芬氟拉明和去甲芬氟拉明的药代动力学
Eur J Clin Pharmacol. 1985;29(2):221-4. doi: 10.1007/BF00547426.
8
Interactions of iprindole with fenfluramine metabolism in rat brain and liver.异吲哚酮与芬氟拉明在大鼠脑和肝脏中的代谢相互作用。
J Psychiatry Neurosci. 1991 Mar;16(1):5-11.
9
Stereoselective disposition of fenfluramine enantiomers in the rat.氟苯丙胺对映体在大鼠体内的立体选择性分布。
Xenobiotica. 1978 Sep;8(9):583-8. doi: 10.3109/00498257809061258.
10
Plasma levels of parent compound and metabolites after doses of either d-fenfluramine or d-3,4-methylenedioxymethamphetamine (MDMA) that produce long-term serotonergic alterations.给予能产生长期5-羟色胺能改变的剂量的右旋芬氟拉明或3,4-亚甲基二氧甲基苯丙胺（摇头丸）后母体化合物和代谢物的血浆水平。
Neurotoxicology. 2003 Jun;24(3):379-90. doi: 10.1016/S0161-813X(03)00030-5.

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In vitro evaluation of fenfluramine and norfenfluramine as victims of drug interactions.氟苯丙胺和去甲氟苯丙胺作为药物相互作用的牺牲品的体外评估。
Pharmacol Res Perspect. 2022 Jun;10(3):e00958. doi: 10.1002/prp2.958.
2
Dose related effect of fenfluramine and norfenfluramine on glucose uptake into human isolated skeletal muscle.芬氟拉明和去甲芬氟拉明对人离体骨骼肌葡萄糖摄取的剂量相关效应。
Br J Clin Pharmacol. 1974 Dec;1(6):511-2. doi: 10.1111/j.1365-2125.1974.tb01703.x.
3
Positron emission tomography study of regional brain metabolic responses to a serotonergic challenge in major depressive disorder with and without comorbid lifetime alcohol dependence.伴有和不伴有终生酒精依赖共病的重度抑郁症患者对5-羟色胺能激发的脑区代谢反应的正电子发射断层扫描研究
Eur Neuropsychopharmacol. 2007 Sep;17(9):608-15. doi: 10.1016/j.euroneuro.2007.03.007. Epub 2007 May 2.
4
The role of drugs in the treatment of obesity.
Drugs. 1981 May;21(5):362-73. doi: 10.2165/00003495-198121050-00004.
5
Proceedings: Effect of fenfluramine and norfenfluramine on glucose uptake by the isolated rat diaphragm.论文集：芬氟拉明和去甲芬氟拉明对离体大鼠膈肌葡萄糖摄取的影响
Br J Pharmacol. 1974 Mar;50(3):477P.
6
Proceedings: Effect of the (minus)- and (plus)-isomers of fenfluramine and norfenfluramine on glucose uptake by the isolated rat hemidiaphragm.论文：芬氟拉明和去甲芬氟拉明的（-）-和（+）-异构体对分离的大鼠半膈肌葡萄糖摄取的影响。
Br J Pharmacol. 1974 May;51(1):120P-121P.
7
Pharmacokinetics of fenfluramine and norfenfluramine in volunteers given D- and DL-fenfluramine for 15 days.给予D-和DL-芬氟拉明15天的志愿者体内芬氟拉明和去甲芬氟拉明的药代动力学
Eur J Clin Pharmacol. 1985;29(2):221-4. doi: 10.1007/BF00547426.
8
Fenfluramine treatment of twenty children with autism.氟苯丙胺治疗二十名自闭症儿童。
J Autism Dev Disord. 1989 Dec;19(4):511-32. doi: 10.1007/BF02212855.
9
Appetite suppressants. A review.食欲抑制剂。一篇综述。
Drugs. 1992 Jun;43(6):820-36. doi: 10.2165/00003495-199243060-00003.
10
Pharmacologically active drug metabolites: therapeutic and toxic activities, plasma and urine data in man, accumulation in renal failure.药理活性药物代谢物：治疗及毒性活性、人体血浆及尿液数据、肾衰竭时的蓄积情况
Clin Pharmacokinet. 1976 Nov-Dec;1(6):426-43. doi: 10.2165/00003088-197601060-00003.

本文引用的文献

1
Gas chromatographic measurement of levels of fenfluramine and norfenfluramine in human plasma, red cells and urine following therapeutic doses.治疗剂量后人体血浆、红细胞和尿液中芬氟拉明和去甲芬氟拉明水平的气相色谱测定。
J Chromatogr. 1970 Jun 24;49(3):442-7. doi: 10.1016/s0021-9673(00)93657-4.