51例帕金森病患者左旋多巴诱发运动障碍的分析。
Analysis of L-dopa induced dyskinesias in 51 patients with Parkinsonism.
作者信息
Mones R J, Elizan T S, Siegel G J
出版信息
J Neurol Neurosurg Psychiatry. 1971 Dec;34(6):668-73. doi: 10.1136/jnnp.34.6.668.
Abstract
An analysis of 51 patients with Parkinsonism who have developed L-dopa induced dyskinesias is presented. The cause has not been proven, although various hypotheses are discussed. One third of the total number of patients treated developed dyskinesia. These patients tend to respond better to L-dopa than the other group. There is a tendency for the older patient or the patient with long-standing disease to develop dyskinesias. There appears to be no way of predicting which patients will develop dyskinesia by analysis of the symptoms or the aetiology of the Parkinsonism syndrome. The unilateral characteristic of the dyskinesia in patients with hemi-Parkinsonism and patients with unilateral thalamotomies suggests that structural abnormalities are critical in determining the presence and localization of dyskinesias. This is supported by non-occurrence of similarly treated patients without Parkinsonism.
摘要
本文对51例已出现左旋多巴诱发运动障碍的帕金森病患者进行了分析。尽管讨论了各种假说，但病因尚未得到证实。接受治疗的患者总数中有三分之一出现了运动障碍。这些患者对左旋多巴的反应往往比另一组更好。老年患者或病程较长的患者有出现运动障碍的倾向。通过分析帕金森综合征的症状或病因，似乎无法预测哪些患者会出现运动障碍。偏侧帕金森病患者和接受单侧丘脑切开术患者的运动障碍具有单侧特征，这表明结构异常在确定运动障碍的存在和定位方面至关重要。未患帕金森病的类似治疗患者未出现运动障碍，这为上述观点提供了支持。
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