颅内低压对脑血流量的影响。
Effect of intracranial hypotension on cerebral blood flow.
作者信息
Salmon J H, Timperman A L
出版信息
J Neurol Neurosurg Psychiatry. 1971 Dec;34(6):687-92. doi: 10.1136/jnnp.34.6.687.
Abstract
Intracranial hypotension increases cerebral blood flow. In dogs the average increase in cortical blood flow was 30 ml./100 g/min (47%) when the intracranial pressure was lowered acutely from 100 to 40 mm CSF. Permanent intracranial hypotension was established in seven demented patients using a ventriculoatrial shunt. The mean post shunt pressure was 50 mm CSF. In this group, the cerebral vascular resistance decreased 32%, the cortical blood flow increased 37%, and the relative weight of functional grey matter increased 44%. The systemic blood pressure was 8% lower. The increase in cerebral blood flow is the result of an increase in the pressure differential between the precapillary arterioles and the veins. In addition, the vessels dilate in response to the decreased external pressure. This increase in cerebral blood flow may be the mechanism for improvement in patients with normal pressure hydrocephalus who are shunted.
摘要
颅内低压会增加脑血流量。在狗身上，当颅内压从100毫米脑脊液急剧降至40毫米脑脊液时，皮质血流量平均增加30毫升/100克/分钟（47%）。使用脑室心房分流术在7名痴呆患者中建立了永久性颅内低压。分流术后平均压力为50毫米脑脊液。在该组中，脑血管阻力降低32%，皮质血流量增加37%，功能性灰质相对重量增加44%。全身血压降低8%。脑血流量增加是毛细血管前小动脉和静脉之间压力差增加的结果。此外，血管会因外部压力降低而扩张。这种脑血流量增加可能是正常压力脑积水患者分流后病情改善的机制。
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