同卵双胞胎中发生的恶性胶质瘤。

J Neurol Neurosurg Psychiatry. 1971 Dec;34(6):718-22. doi: 10.1136/jnnp.34.6.718.

The occurrence of malignant gliomas in a pair of identical twins is reported. One, in the posterior fossa, presented in the third year of life, the other, in the left cerebral hemisphere, in the eighth. Both ran a rapidly progressive course and died within a few months of the onset of symptoms. The histological structure of the gliomas was similar and both tumours consisted of astrocytic and oligodendroglial parts. Review of the literature revealed only two pairs of histologically proven gliomas occurring in identical twins. The number of cases reported is too small for any valid conclusions on possible genetic mechanisms.

本文报道了一对同卵双胞胎患恶性胶质瘤的病例。其中一人的肿瘤位于后颅窝，发病于3岁；另一人的肿瘤位于左侧大脑半球，发病于8岁。两人的病程均呈快速进展，在症状出现后的几个月内死亡。胶质瘤的组织结构相似，两个肿瘤均由星形胶质细胞和少突胶质细胞成分组成。文献回顾显示，仅有两对经组织学证实的同卵双胞胎患胶质瘤的病例。报告的病例数量过少，无法就可能的遗传机制得出任何有效结论。