Cartwright S C
Clin Pediatr (Phila). 1982 Apr;21(4):236-8. doi: 10.1177/000992288202100408.
The occurence is reported of optic chiasma gliomas in a pair of identical twins, both with neurofibromatosis. One twin developed precocious puberty in the sixth year of life and was shown by cisternal computerized tomography to have a supersellar tumor, which proved to be a malignant glioma. The second twin had an abnormal growth spurt but not overt precocious puberty. Cisternal computerized tomography of the second twin revealed evidence of a similar, smaller tumor at the same site. The literature is reviewed and some possible genetic explanations discussed. This report also emphasises the importance of careful investigation of the second twin when a malignancy is found in one, irrespective of the site or type of the tumor.
据报道，一对患有神经纤维瘤病的同卵双胞胎均出现了视交叉神经胶质瘤。其中一名双胞胎在6岁时出现性早熟，经脑池计算机断层扫描显示有鞍上肿瘤，病理证实为恶性胶质瘤。另一名双胞胎有生长加速但无明显性早熟。对其进行脑池计算机断层扫描发现，在同一部位有一个类似的较小肿瘤。本文回顾了相关文献并讨论了一些可能的遗传学解释。本报告还强调，当其中一名双胞胎被发现患有恶性肿瘤时，无论肿瘤的部位或类型如何，都要对另一名双胞胎进行仔细检查。
