Gupta B N, Khanna R N, Datta K K
Toxicology. 1979 May;13(1):45-9.
A 90-day study involving administration of O (group 1), 100 (group 2), 250 (group 3) and 500 mg/kg (group 4) of ammonium sulfamate to rats 6 days a week was carried out. No adverse effect was observed in respect of appearance, behaviour or survival of animals. No significant difference in the body weights of rats was observed except in case of adult rats (group 4) where the body weight was significantly less than the controls after the end of 60 days. In all the groups food intake gradually reduced whereas water intake increased as the experiment proceeded. No significant change in relative organ weights were noticed in all groups of rats. Haematological examination conducted at 30, 60 and 90 days revealed non-significant increase in the neutrophils in the adults and male weanling rats (group 4) after 90 days. In the histological examination, organs in all the groups of animals appeared normal except that the liver of 1 rat in adults (group 4) showed slight fatty degenerative changes after 90 days.
开展了一项为期90天的研究，每周6天给大鼠施用氨基磺酸铵，剂量分别为0（第1组）、100（第2组）、250（第3组）和500毫克/千克（第4组）。在动物的外观、行为或存活方面未观察到不良反应。除成年大鼠（第4组）外，未观察到大鼠体重有显著差异，在60天结束时，成年大鼠（第4组）的体重明显低于对照组。随着实验进行，所有组的食物摄入量逐渐减少，而饮水量增加。所有组大鼠的相对器官重量均未发现显著变化。在第30、60和90天进行的血液学检查显示，成年大鼠和雄性断奶大鼠（第4组）在90天后中性粒细胞有不显著增加。在组织学检查中，所有组动物的器官均正常，只是成年大鼠（第4组）中有1只大鼠的肝脏在90天后出现轻微脂肪变性变化。
