Trott K R, Heinze H G, Kiesel B, Kollmann G, Kummermehr J
Strahlentherapie. 1979 Nov;155(11):748-53.
The growth of 148 untreated metastases to the lung was determined in 47 patients. Pulmonary metastases of squamous-cell carcinomas, sarcomas and malignant melanomas exhibited exponential growth, the doubling times were distributed log-normally, the geometric mean amounted to six weeks. The growth rate of adenocarcinomas decreased with increasing tumor size approximately in accordance with a Gompertzian function.
在47例患者中确定了148个未经治疗的肺转移瘤的生长情况。鳞状细胞癌、肉瘤和恶性黑色素瘤的肺转移瘤呈指数生长,倍增时间呈对数正态分布,几何平均值为六周。腺癌的生长速率随肿瘤大小增加而降低,大致符合冈珀茨函数。