Wambersie A, Laublin G, Octave-Prignot M, Meulders J P
Strahlentherapie. 1979 Nov;155(11):776-85.
RBE/absorbed dose relationship of d(50)-Be neutrons was determined for the induction of chromosome aberrations in Allium cepa onion roots. Neutrons are produced at the cyclotron "Cyclone" by bombarding a thick beryllium target with 50 MeV deuterons. Two biological criteria were selected: (1) mean number of aberrations (mainly breaks) per cell in anaphase and telophase, (2) fraction of intact cells in anaphase and telophase. For the two criteria, RBE increases continuously from about 7 to 12 as the neutron absorbed dose decreases from 0.4 to 0.1 Gy. RBE values for the first criterion are slightly higher than for the second one. This observation is interpreted in terms of the analysis of the distribution of the aberrations in the cells. In logarithmic coordinates, RBE/absorbed dose relationships for the two criteria are almost linear with a slope close to -1/2. RBE values observed for induction of chromosome aberrations in Allium cepa are higher than those generally observed for biological effects related to mammalian cell lethality.
测定了d(50)-铍中子在洋葱根尖细胞中诱导染色体畸变的相对生物学效应（RBE）与吸收剂量的关系。中子是在回旋加速器“Cyclone”中通过用50兆电子伏特的氘核轰击厚铍靶产生的。选择了两个生物学指标：（1）后期和末期每个细胞的畸变（主要是断裂）平均数；（2）后期和末期完整细胞的比例。对于这两个指标，当中子吸收剂量从0.4戈瑞降至0.1戈瑞时，RBE从约7持续增加至12。第一个指标的RBE值略高于第二个指标。根据细胞中畸变分布的分析对这一观察结果进行了解释。在对数坐标中，两个指标的RBE/吸收剂量关系几乎呈线性，斜率接近-1/2。在洋葱根尖中观察到的诱导染色体畸变的RBE值高于通常观察到的与哺乳动物细胞致死性相关的生物学效应的RBE值。
