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用于诱导小鼠精原细胞中染色体重排的氘(16)+铍和氘(50)+铍中子的相对生物效应值。

RBE values of d (16) + Be and d (50) + Be neutrons for chromosome rearrangements induced in mouse spermatogonia.

作者信息

Pécrot M, Léonard A, Wambersie A, Meulders J P

出版信息

Strahlentherapie. 1977 Jun;153(6):423-5.

PMID:877978
Abstract

The rate of reciprocal translocations induced in mouse spermatogonia by exposure to X-rays and to neutrons produced by 16 and 50 MeV deuterons has been estimated by scoring multivalent configurations in the descendant spermatocytes. In the X-irradiated group the yield of translocations increases from 2,1 per 100 cells after exposure to 100 rad to 5,7 after exposure to 300 rad. The dose-response relationship shows no statistical departure from linearity. After exposure to 50, 100 or 150 rad of d (16) + Be and d (50) + Be neutrons, the yield of translocations displays a humped curve. Up to this dose the RBE value decreases with absorbed dose and neutron energy.

摘要

通过对后代精母细胞中的多价构型进行评分,估算了小鼠精原细胞暴露于X射线以及由16和50兆电子伏特氘核产生的中子后诱发相互易位的发生率。在X射线照射组中,易位发生率从暴露于100拉德后的每100个细胞2.1增加到暴露于300拉德后的5.7。剂量反应关系未显示出与线性有统计学偏差。暴露于50、100或150拉德的d(16)+铍和d(50)+铍中子后,易位发生率呈现出驼峰曲线。在此剂量之前,相对生物效应值随吸收剂量和中子能量而降低。

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