Supe S J
Strahlentherapie. 1979 Dec;155(12):833-40.
With discrete radiation sources, it is a deliberate treatment policy to provide gaps between two implantations of radioactive sources. Gap correction formulae have been arrived at to evaluate the ultimate biological effect on tissue. These formulae do not maintain the identity of the CRE and TDF concepts and hence Supe and Supe have chosen for external beam treatments appropriate gap corrections which maintain the equivalence of the concepts. During the continuous radiation therapy the tissue cells have a tendency to clump together in the sensitive phase and hence the radiation dose is more effective in this mode of treatment. Consequently the mathematical expressions for the CRE and TDFs for continuous radiation therapy differ from those for external beam therapy. The formula for complex treatment schedules of external beam therapy will not apply to those in brachytherapy, have been arrived at. In order to simplify the evaluation of the effective biological effects Tables for value of (T1+G1/T1)-0.155 and CRE0.71 have been prepared. The formulae developed for the resultant CREs and TDFs for the combination of brachytherapy treatments with gaps are different than those for combinations of external beam therapy. The powers of CRE and the terms of the type (T1+G1/T1) have changed appreciably.
对于离散辐射源，在两次放射性源植入之间留出间隙是一种刻意的治疗策略。已经得出了间隙校正公式，以评估对组织的最终生物学效应。这些公式并未保持CRE和TDF概念的一致性，因此苏佩和苏佩为外照射治疗选择了合适的间隙校正方法，以保持这些概念的等效性。在连续放射治疗期间，组织细胞在敏感阶段有聚集在一起的趋势，因此在这种治疗模式下辐射剂量更有效。因此，连续放射治疗的CRE和TDF的数学表达式与外照射治疗的不同。已经得出，外照射治疗复杂治疗方案的公式不适用于近距离治疗的方案。为了简化有效生物学效应的评估，已经编制了（T1 + G1/T1）-0.155值和CRE0.71值的表格。为有间隙的近距离治疗组合得出的最终CRE和TDF公式与外照射治疗组合的公式不同。CRE的幂和（T1 + G1/T1）类型的项有明显变化。
