Väyrynen T, Kiviniitty K, Kauppila A
Strahlentherapie. 1981 Jun;157(6):396-9.
The CRE concept is not applicable to the assessment of the effect of combined radiotherapy when external and intracavitary radiations are given alternately and with unequal doses. Because of the numerous recurrences, we had to change our radiation treatment schemes for carcinoma cervix uteri, and we attempted, on a theoretical basis, to acquire the same biological effects as Joslin with his own method. In the comparison of different schemes we used as slightly modified approximate CRE and the "nominal dose" presented by Kellerer. In this paper we have presented the treatment schemes we used and the methods for calculating the biological effect in combined treatments. Moreover, we have examined the applicability and compatibility of the above methods in comparing the effects of different combined radiation treatment schemes.
当外照射和腔内照射交替进行且剂量不等时，等效生物剂量（CRE）概念不适用于评估联合放疗的效果。由于复发情况众多，我们不得不改变子宫颈癌的放疗方案，并在理论基础上尝试采用与乔斯林自己的方法相同的生物学效应。在比较不同方案时，我们使用了略有修改的近似等效生物剂量（CRE）和凯勒尔提出的“标称剂量”。在本文中，我们介绍了所使用的治疗方案以及联合治疗中生物学效应的计算方法。此外，我们还研究了上述方法在比较不同联合放疗方案效果时的适用性和兼容性。
