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垂体和肾上腺在介导酒精对小鼠睾丸类固醇生成的影响中的作用。

Role of the pituitary and the adrenals in mediating the effects of alcohol on testicular steroidogenesis in mice.

作者信息

Badr F M, Smith M S, Dalterio S L, Bartke A

出版信息

Steroids. 1979 Oct;34(4):477-82. doi: 10.1016/0039-128x(79)90108-9.

DOI:10.1016/0039-128x(79)90108-9
PMID:516113
Abstract

We have previously demonstrated that intragastric administration of alcohol (1.24 g/kg body wt) to adult male mice results in suppression of testosterone production. We now report that the decline in peripheral testosterone levels in alcohol-treated mice is not accompanied by changes in plasma levels of luteinizing hormone, follicle stimulating hormone or estradiol-17 beta, and that it is markedly attenuated in adrenalectomized or adrenalectomized-corticosterone treated males.

摘要

我们之前已经证明,给成年雄性小鼠胃内注射酒精(1.24克/千克体重)会导致睾酮生成受到抑制。我们现在报告,酒精处理的小鼠外周睾酮水平的下降并未伴随促黄体生成素、促卵泡激素或雌二醇-17β血浆水平的变化,并且在肾上腺切除或肾上腺切除-皮质酮处理的雄性小鼠中这种下降明显减弱。

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Role of the pituitary and the adrenals in mediating the effects of alcohol on testicular steroidogenesis in mice.垂体和肾上腺在介导酒精对小鼠睾丸类固醇生成的影响中的作用。
Steroids. 1979 Oct;34(4):477-82. doi: 10.1016/0039-128x(79)90108-9.
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引用本文的文献

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Inhibition of testosterone biosynthesis by ethanol. Relation to hepatic and testicular acetaldehyde, ketone bodies and cytosolic redox state in rats.乙醇对睾酮生物合成的抑制作用。与大鼠肝脏和睾丸中的乙醛、酮体及胞质氧化还原状态的关系。
Biochem J. 1983 Jan 15;210(1):29-36. doi: 10.1042/bj2100029.