Demidov S V, El'skaia A V
Ukr Biokhim Zh (1978). 1979 Sep-Oct;51(5):503-7.
The rabbit liver tRNA was studied in such functional states when there occurred essential qualitative and quantitative changes in the protein synthesis. On the basis of the maximum level of aminoacylation it is established that the contents of corresponding biologically active individual tRNA in the total preparation for adult animals is 1.5-3 times as high as that for 3-5 day rabbits. Exception is alanine tRNA whose number decreases sharply in the total preparation of the liver tRNA of one- and two-year animals. No correlation was found for any age group between the quantitative ratio of active individual tRNA and the amino acid composition of albumins whose synthesis in the liver is intensive. Thus, the synthesis and, respectively, the content of certain types of tRNA in the liver characterized by a wide spectrum of proteins with different functions are governed by other regularities, whose search is one of the most difficult and at the same time high-promising problems.
在蛋白质合成发生本质性的定性和定量变化时，对处于这种功能状态下的兔肝tRNA进行了研究。根据氨酰化的最高水平确定，成年动物总制剂中相应生物活性个体tRNA的含量是3至5日龄兔的1.5至3倍。丙氨酸tRNA是个例外，其在一岁和两岁动物肝tRNA总制剂中的数量急剧减少。对于任何年龄组，在肝脏中大量合成的白蛋白的活性个体tRNA的定量比例与其氨基酸组成之间均未发现相关性。因此，肝脏中某些类型tRNA的合成以及相应含量（其特征是具有广泛不同功能的蛋白质）受其他规律支配，寻找这些规律是最困难但同时也是最有前景的问题之一。
