[鸟类嘧啶核苷酸生物合成的两条途径]
[Two pathways of pyrimidine nucleotide biosynthesis in birds].
作者信息
Tkachuk A M, Kokunin V A
出版信息
Ukr Biokhim Zh (1978). 1979 Sep-Oct;51(5):520-4.
Dillerent chicken tissues are shown to display a clearly pronounced specificity relative to [2-14C] orotic acid and [5-3H]uridine as precursors of synthesis of the pool and RNA pyrimidine nucleotides. The fraction of pyrimidine nucleotides synthetized relative to the reserve pathway (uridine utilization) decreases in the series: kidneys greater than duodenum mucosa greater than lungs greater than liver greater than pancreas greater than bone marrow greater than brain greater than spleen. The results of [2-14C]orotic acid and [53H]uridine incorporation into UMP and CMP of the liver and spleen tissues RNA are interpreted in terms of the concept on existence of separate pools of pyrimidine phosphates--RNA precursors.
不同的鸡组织相对于作为合成库和RNA嘧啶核苷酸前体的[2-¹⁴C]乳清酸和[5-³H]尿苷显示出明显的特异性。相对于储备途径（尿苷利用）合成的嘧啶核苷酸比例在以下序列中降低：肾脏＞十二指肠黏膜＞肺＞肝脏＞胰腺＞骨髓＞脑＞脾脏。根据嘧啶磷酸——RNA前体存在单独库的概念，解释了[2-¹⁴C]乳清酸和[5-³H]尿苷掺入肝脏和脾脏组织RNA的UMP和CMP中的结果。
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