[雏鸡组织中乳清酸代谢的动力学]
[Dynamics of orotic acid metabolism in chick tissues].
作者信息
Tkachuk A M, Kokunin V A
出版信息
Ukr Biokhim Zh (1978). 1979 Jan-Feb;51(1):66-72.
The processes of pyrimidine nucleotides metabolism were analyzed in cells of chicken small intestine mucosa using the kinetic series-parallel model of the first order equations. The rate constants are calculated for absorption of [2-14C]orotic acid by mucosa cells, its accumulation in blood anc conversion to uridine nucleotides. Stages of uridine nucleotides conversion to cytidine ones and their incorporation into RNA are not described by the system of the first order equations based on the series-parallel model with the single-channel utilization of orotic acid through the pyrimidine pathway. The model into two pathways of free nucleotides metabolism and two individual flows of precursors into RNA corresponds qualitatively to the obtained experimental data. Metabolism of orotic acid along two separate channels might be typical of the chicken liver.
利用一级方程的动力学串并联模型分析了鸡小肠黏膜细胞中嘧啶核苷酸的代谢过程。计算了黏膜细胞对[2-¹⁴C]乳清酸的吸收速率常数、其在血液中的积累以及转化为尿苷核苷酸的速率常数。基于乳清酸通过嘧啶途径单通道利用的串并联模型，一级方程组未描述尿苷核苷酸转化为胞苷核苷酸的阶段及其掺入RNA的过程。该模型将游离核苷酸代谢分为两条途径以及将前体分为两条独立流入RNA的途径，在性质上与获得的实验数据相符。乳清酸沿两条独立通道的代谢可能是鸡肝脏的典型特征。
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