各种药物对发酵性链球菌溶血活性的影响。
Effects of various drugs on hemolytic activity of Streptococcus zymogenes.
作者信息
Werth J M, Jackson R W
出版信息
J Bacteriol. 1971 Nov;108(2):844-8. doi: 10.1128/jb.108.2.844-848.1971.
Abstract
Drugs known to interrupt the chain of protein synthesis (streptomycin, chloramphenicol, ethidium bromide) appeared to affect production of the group D lysin by Streptococcus zymogenes by inhibiting growth. Drugs which block cell wall synthesis (vancomycin, bacitracin, d-cycloserine, and phosphonomycin) inhibited lytic activity by a mechanism independent of growth. Bacitracin appeared not to have a major effect on lysin production but elicited the production of an inhibitor of lytic activity.
摘要
已知能中断蛋白质合成链的药物（链霉素、氯霉素、溴化乙锭）似乎通过抑制生长来影响发酵链球菌产生D组溶素。阻断细胞壁合成的药物（万古霉素、杆菌肽、d-环丝氨酸和磷霉素）通过一种与生长无关的机制抑制裂解活性。杆菌肽似乎对溶素产生没有主要影响，但能引发一种裂解活性抑制剂的产生。
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