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Studies of catalysis by acetylcholinesterase. I. Fluorescent titration with a carbamoylating agent.

作者信息

Rosenberry T L, Bernhard S A

出版信息

Biochemistry. 1971 Oct 26;10(22):4114-20. doi: 10.1021/bi00798a016.

DOI:10.1021/bi00798a016
PMID:5168614
Abstract
摘要

相似文献

1
Studies of catalysis by acetylcholinesterase. I. Fluorescent titration with a carbamoylating agent.乙酰胆碱酯酶催化作用的研究。I. 用氨基甲酰化剂进行荧光滴定。
Biochemistry. 1971 Oct 26;10(22):4114-20. doi: 10.1021/bi00798a016.
2
The reaction of acetylcholinesterase (AChe) with some quaternary hydroxy aminophenols.乙酰胆碱酯酶(AChe)与某些季铵化羟基氨基酚的反应。
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Identification of a modifier site on acetylcholinesterase with affinity for d-tubocurarine.
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Fluorescent probes of acetylcholinesterase.
Biochemistry. 1972 Apr 25;11(9):1595-602. doi: 10.1021/bi00759a008.
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The reaction of acetylcholinesterase with O-dimethylcarbamyl esters of quaternary quinolinium compounds.乙酰胆碱酯酶与季铵喹啉化合物的O-二甲基氨基甲酰酯的反应。
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A comparative study of the interactions of the nonpolar fluorescent ligand, 1-anilino-8-naphthalene sulfonic acid, with butyryl and acetylcholinesterase.非极性荧光配体1-苯胺基-8-萘磺酸与丁酰胆碱酯酶和乙酰胆碱酯酶相互作用的比较研究
Arch Biochem Biophys. 1971 Jul;145(1):169-78. doi: 10.1016/0003-9861(71)90024-5.
7
Effect of charge on the carbamylation and binding constants of eel acetylcholinesterase in reaction with neostigmine and related carbamates.电荷对鳗鱼乙酰胆碱酯酶与新斯的明及相关氨基甲酸酯反应的氨甲酰化和结合常数的影响。
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Studies of catalysis by acetylcholinesterase. Synergistic effects of inhibitors during the hydrolysis of acetic acid esters.乙酰胆碱酯酶催化作用的研究。乙酸酯水解过程中抑制剂的协同效应。
Biochemistry. 1972 Nov 7;11(23):4308-21. doi: 10.1021/bi00773a018.
9
Spontaneous reactivation of acetylcholinesterase inhibited with para-substituted phenyl methylphosphonochloridates.被对取代苯基甲基膦酰氯抑制的乙酰胆碱酯酶的自发复活
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The reaction of acetylcholinesterase with methanesulfonyl esters of quaternary quinolinium compounds.乙酰胆碱酯酶与季铵喹啉化合物甲磺酸酯的反应。
Biochem Pharmacol. 1969 Feb;18(2):269-78. doi: 10.1016/0006-2952(69)90204-4.

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Rate-limiting step in the decarbamoylation of acetylcholinesterases with large carbamoyl groups.具有大的氨基甲酰基的乙酰胆碱酯酶脱氨基甲酰化的限速步骤。
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Decarbamoylation of acetylcholinesterases is markedly slowed as carbamoyl groups increase in size.
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Crystal structure of thioflavin T bound to the peripheral site of Torpedo californica acetylcholinesterase reveals how thioflavin T acts as a sensitive fluorescent reporter of ligand binding to the acylation site.与加州电鳐乙酰胆碱酯酶外周位点结合的硫黄素T的晶体结构揭示了硫黄素T如何作为配体与酰化位点结合的灵敏荧光报告分子。
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