Ulitovskiĭ D A, Konnov B A
Zh Nevropatol Psikhiatr Im S S Korsakova. 1976 Sep;76(9):1337-41.
In order to study the clinical picture due to inrradiation of the hypophysis by protons with an energy of 1000 Mev with the use of a pendulum technique, the authors examined 30 dogs including 27 with an irradiated hypophysis and 3 control animals during 2 years. The results were verified in autopsies and in histological studies. These examinations demonstrated frequent general cerebral symptoms, focal neurological and hypophysis-endocrinological symptoms as well as frequent lesions of the cranial nerves, epileptic seizures and nonsymptomatic focal brain necrosis. It was also possible to demonstrate a correlation of the clinical traits with the dosage of the irradiation and the time past after irradiation. The report contains corrections for using these data on humans.
为了利用摆动技术研究能量为1000兆电子伏的质子照射垂体后的临床表现，作者在两年内检查了30只狗，其中27只垂体接受了照射，3只为对照动物。结果在尸检和组织学研究中得到了验证。这些检查显示出频繁出现的全身性脑症状、局灶性神经症状和垂体 - 内分泌症状，以及频繁出现的颅神经病变、癫痫发作和无症状性局灶性脑坏死。还能够证明临床特征与照射剂量和照射后经过的时间之间的相关性。该报告包含了将这些数据应用于人类的修正内容。
