孕期甲状腺毒症药物治疗并发胎儿甲状腺功能减退症。

Fetal hypothyroidism complicating medical treatment of thyrotoxicosis in pregnancy.

作者信息

Ibbertson H K, Seddon R J, Croxson M S

出版信息

Clin Endocrinol (Oxf). 1975 Sep;4(5):521-3. doi: 10.1111/j.1365-2265.1975.tb01563.x.

DOI:10.1111/j.1365-2265.1975.tb01563.x

Abstract

Two women with thyrotoxicosis were treated with antithyroid drugs during pregnancy. One women had inadvertently received a therapeutic dose of radioiodine at 21 weeks gestation and the other suffered from severe thyrotoxicosis with a serum LATS level of 1850%. In both patients, the serum triiodothyronine was maintained above 500 ng/dl by the concurrent oral administration of this hormone. Despite this precaution, cord serum thyrotrophin levels were markedly elevated and both infants showed clinical signs of hypothyroidism at birth. This experience indicates that triiodothyronine does not prevent fetal hypothyroidism when given to the mother in pharmacological amounts.

摘要

两名患有甲状腺毒症的女性在孕期接受了抗甲状腺药物治疗。其中一名女性在妊娠21周时不慎接受了治疗剂量的放射性碘，另一名患有严重甲状腺毒症，血清长效甲状腺刺激素（LATS）水平为1850%。在两名患者中，通过同时口服该激素，血清三碘甲状腺原氨酸水平维持在500 ng/dl以上。尽管采取了这一预防措施，脐血促甲状腺素水平仍显著升高，两名婴儿出生时均表现出甲状腺功能减退的临床症状。这一经验表明，当以药理剂量给予母亲时，三碘甲状腺原氨酸并不能预防胎儿甲状腺功能减退。