Georgiev M
Acta Chir Iugosl. 1979;26(2):89-95.
The author presented his observations of a small group of rabbits to which he administered small doses of dopamine under conditions of warm ischemia (the time between the clamping of the renal artery till the beginning of hypothermic extracorporeal circulation). Another group of rabbits did not receive dopamine. Those rabbits that were given dopamine lived longer and were more resistant to uremia and toxemia. The effect of dopamine lived longer and were more resistant to uremia and toxemia. The effect of dopamine is thought to be due to its vasodilator action on the kidney during periods of hyoxia ad hypotension. The author explained that the kidneys withstood three hours of warm ischemia when treated with dopamine. p.s. This paper is an abstract from the authors dissertation: Protective Action of Dopamine on the Kidney Damaged During Warm Ischemia.
作者介绍了他对一小群兔子的观察结果,他在热缺血(从肾动脉夹闭到低温体外循环开始的这段时间)条件下给这些兔子注射了小剂量多巴胺。另一组兔子未接受多巴胺。那些注射了多巴胺的兔子存活时间更长,对尿毒症和毒血症的抵抗力更强。多巴胺的作用持续时间更长,对尿毒症和毒血症的抵抗力更强。多巴胺的作用被认为是由于其在缺氧和低血压期间对肾脏的血管舒张作用。作者解释说,用多巴胺治疗时,肾脏能耐受三小时的热缺血。附言:本文是作者博士论文《多巴胺对热缺血期间受损肾脏的保护作用》的摘要。