Escudero E, Fraile A
Agents Actions. 1979 Oct;9(4):310-3. doi: 10.1007/BF01970653.
The metabolism of histamine has been compared in Rana ridibunda and Discoglossus pictus, both Amphibia anura. An intralymphatic injection of 14C-histamine (5 microCi) was administered to the animals and the total radioactivity excreted in the urine was measured 24, 48, and 72 hours later. The metabolites excreted in the urine at 24 hours were analyzed by thin-layer chromatography and subsequent autoradiography. In both species approximately 60--70% of the injected dose was found in the urine by 72 hours. In Rana ridibunda two histamine metabolites were found: imidazoleacetic and methylimidazoleacetic acid. The present results suggest that the catabolism of histamine differs in the two species.
对欧洲林蛙和黄斑盘舌蟾这两种无尾两栖动物的组胺代谢进行了比较。给动物进行淋巴管内注射14C-组胺（5微居里），并在24、48和72小时后测量尿液中排出的总放射性。通过薄层色谱法和随后的放射自显影分析24小时时尿液中排出的代谢物。在这两个物种中，到72小时时，约60%-70%的注射剂量在尿液中被发现。在欧洲林蛙中发现了两种组胺代谢物：咪唑乙酸和甲基咪唑乙酸。目前的结果表明，这两个物种中组胺的分解代谢有所不同。
