Hendry I A
Brain Res. 1976 Apr 30;107(1):105-16. doi: 10.1016/0006-8993(76)90098-6.
The effects of surgical transection of the postganglionic nerve trunk of the superior cervical ganglion on the total protein content and levels of the enzymes tyrosine hydroxylase, DOPA decarboxylase and choline acetyltransferase have been studied in the adult rat. There is a minor decrease in the total activities of these 3 enzymes accompanied by a large increase in the total protein content of the ganglion. The trans-synaptic induction of the enzyme tyrosine hydroxylase by reserpine is not affected by postganglionic axotomy. Increased activity mediated by reserpine caused no change in the total activities of either DOPA decarboxylase or choline acetyltransferase. Previously observed effects of postganglionic axotomy on preventing transmission through the ganglion are compared with these results and the possible mechanisms by which trans-synaptic induction may occur are discussed.
在成年大鼠中，研究了切断颈上神经节节后神经干对总蛋白含量以及酪氨酸羟化酶、多巴脱羧酶和胆碱乙酰转移酶水平的影响。这三种酶的总活性略有下降，同时神经节的总蛋白含量大幅增加。利血平对酪氨酸羟化酶的跨突触诱导不受节后轴突切断的影响。利血平介导的活性增加并未导致多巴脱羧酶或胆碱乙酰转移酶的总活性发生变化。将先前观察到的节后轴突切断对阻止神经节传递的影响与这些结果进行了比较，并讨论了跨突触诱导可能发生的潜在机制。
