Hendry I A
Brain Res. 1975 Jun 13;90(2):235-44. doi: 10.1016/0006-8993(75)90304-2.
The effects of division of the postganglionic axons of the adrenergic neurones in the superior cervical ganglion of the rat were examined with regard to the total ganglionic protein content and tyrosine hydroxylase and DOPA decarboxylase activities. Axotomy before the twelfth postnatal day results in a marked atrophy of the ganglion and a reduction in the total enzyme content of the ganglion. Axotomy after postnatal day 21 results in the normal adult ganglion response with a large increase in the total protein content of the ganglion and only minor changes in the total enzyme content of the ganglion. Axotomy between the postnatal days 12 and 21 results in an intermediate response. Thus it can be concluded there is a critical period during the development of the ganglion during which the adrenergic neurones undergo a maturation governed by their contact with the peripheral target cell via axons. These results suggest a trophic role of the end organ on the adrenergic neurone.
就颈上神经节中肾上腺素能神经元节后轴突的切断对神经节总蛋白含量以及酪氨酸羟化酶和多巴脱羧酶活性的影响进行了研究。出生后第12天之前进行轴突切断会导致神经节明显萎缩，且神经节总酶含量降低。出生后第21天之后进行轴突切断会导致神经节出现正常的成年期反应，神经节总蛋白含量大幅增加，而神经节总酶含量仅有微小变化。出生后第12天至21天之间进行轴突切断会导致中间型反应。因此可以得出结论，在神经节发育过程中存在一个关键时期，在此期间肾上腺素能神经元通过轴突与外周靶细胞的接触经历成熟过程。这些结果表明终末器官对肾上腺素能神经元具有营养作用。
