Schanzlin D J, Jay W H, Fritz K J, Tripathi R C, Gonen B
Am J Ophthalmol. 1979 Dec;88(6):1032-8. doi: 10.1016/0002-9394(79)90412-4.
The levels of the minor hemoglobin A1 components were measured in a consecutive series of 102 diabetic patients who were extensively studied for signs of diabetic retinopathy. We found a statistically significant relationship between metabolic control, as reflected by the hemoglobin A1 level, and the severity of diabetic retinopathy in patients with diabetes diagnosed before 30 years of age (P less than or equal to .001). We did not demonstrate a significant correlation between metabolic control and the severity of retinopathy in patients with diabetes diagnosed after the age of 30 years. We found significantly more severe retinopathy among patients with longer duration of the disease, in men, in whites, in diabetics diagnosted before 30 years of age who were treated with lower insulin doses, and in obses patients with the onset of diabetes after the age of 30 years.
对连续102例糖尿病患者进行了研究，这些患者均接受了糖尿病视网膜病变体征的全面检查，并检测了次要血红蛋白A1成分的水平。我们发现，对于30岁之前被诊断为糖尿病的患者，糖化血红蛋白水平所反映的代谢控制情况与糖尿病视网膜病变的严重程度之间存在统计学上的显著关系（P≤0.001）。而对于30岁之后被诊断为糖尿病的患者，我们并未证明代谢控制与视网膜病变严重程度之间存在显著相关性。我们发现，病程较长的患者、男性患者、白人患者、30岁之前被诊断为糖尿病且胰岛素剂量较低的患者，以及30岁之后发病的肥胖患者，其视网膜病变更为严重。
