Oishi N, Kubo E, Takamura Y, Maekawa K, Tanimoto T, Akagi Y
Department of Ophthalmology, Fukui Medical University, Japan.
Br J Ophthalmol. 2002 Dec;86(12):1363-6. doi: 10.1136/bjo.86.12.1363.
To examine the relation between aldose reductase (AR) and the development and progression of diabetic retinopathy by comparing the erythrocyte AR levels with the prevalence of diabetic retinopathy in NIDDM patients.
A clinic based cross sectional study was used. 611 NIDDM patients and 73 controls were enrolled. Erythrocyte AR levels were determined by ELISA. These AR levels were then correlated with patient age, duration of diabetes, and HbA(1c) levels. AR levels were also correlated with the prevalence of diabetic retinopathy in the entire NIDDM patient group and in three subgroups formed by separating the NIDDM patients by their duration of diabetes. The prevalence of diabetic retinopathy significantly increased with increased erythrocyte AR levels in patients with duration of diabetes of less than 10 years. A similar, but non-significant correlation between the prevalence of retinopathy and increased erythrocyte AR levels was observed in patients with diabetes duration of 10-20 and >/=20 years.
The prevalence of diabetic retinopathy increased with increased erythrocyte AR levels in NIDDM patients with a duration of diabetes of less than 10 years.
It was suggested that the inhibition of AR in patients with early NIDDM might be beneficial in reducing the development of diabetic retinopathy.
通过比较非胰岛素依赖型糖尿病（NIDDM）患者的红细胞醛糖还原酶（AR）水平与糖尿病视网膜病变的患病率，研究AR与糖尿病视网膜病变发生及进展之间的关系。
采用基于门诊的横断面研究。纳入611例NIDDM患者和73例对照。用酶联免疫吸附测定法（ELISA）测定红细胞AR水平。然后将这些AR水平与患者年龄、糖尿病病程及糖化血红蛋白（HbA1c）水平进行相关性分析。AR水平还与整个NIDDM患者组以及根据糖尿病病程将NIDDM患者分成的三个亚组中的糖尿病视网膜病变患病率进行相关性分析。糖尿病病程小于10年的患者中，糖尿病视网膜病变的患病率随红细胞AR水平升高而显著增加。糖尿病病程为10 - 20年及≥20年的患者中，视网膜病变患病率与红细胞AR水平升高之间存在相似但无统计学意义的相关性。
糖尿病病程小于10年的NIDDM患者中，糖尿病视网膜病变的患病率随红细胞AR水平升高而增加。
提示早期NIDDM患者抑制AR可能有助于减少糖尿病视网膜病变的发生。
