Fahrenkrug J, Schaffalitzky de Muckadell O B, Holst J J, Jensen S L
Am J Physiol. 1979 Dec;237(6):E535-40. doi: 10.1152/ajpendo.1979.237.6.E535.
The role of nerves that liberate vasoactive intestinal polypeptide (VIP) in the porcine pancrease as mediators of the atropine-resistant action of the vagus on flow and bicarbonate (HCO3) secretion was examined. Efferent electrical stimulation of the vagus in atropinized pigs produced a profuse flow of pancreatic juice with high HCO3 content concomitantly with a significant increase in pancreatic VIP output from 13 to 113 fmol/min. Intravenous administration of somatostatin (SRIF) during continuous electrical vagal stimulation caused a parallel suppression of the VIP release and the pancreatic fluid and HCO3 secretion to prestimulatory values. The SRIF-induced reduction in fluid and HCO3 secretion seemed to be mediated via an inhibition of the VIP release rather than through a direct effect on the exocrine cells, inasmuch as SRIF did not influence the VIP-provoked exocrine response from the in vitro isolated perfused porcine pancreas. The results support the view that VIP is transmitter in the vagally induced atropine-resistant water and HCO3 secretion from the porcine pancreas.
研究了猪胰腺中释放血管活性肠肽（VIP）的神经作为迷走神经对胰液分泌和碳酸氢盐（HCO3）分泌产生阿托品抵抗作用的介质的作用。在阿托品化的猪中，对迷走神经进行传出电刺激会产生大量含高HCO3含量的胰液，同时胰腺VIP输出量从13 fmol/分钟显著增加至113 fmol/分钟。在持续迷走神经电刺激期间静脉注射生长抑素（SRIF）会使VIP释放以及胰液和HCO3分泌平行抑制至刺激前水平。SRIF引起的胰液和HCO3分泌减少似乎是通过抑制VIP释放介导的，而非直接作用于外分泌细胞，因为SRIF不影响体外分离灌注的猪胰腺对VIP激发的外分泌反应。这些结果支持以下观点：VIP是猪胰腺迷走神经诱导的阿托品抵抗性水和HCO3分泌中的递质。
