Kristt D A
Anat Embryol (Berl). 1979 Oct;157(2):217-26. doi: 10.1007/BF00305161.
In this ontogenetic study the neurons of layer VIb of rodent somatosensory cortex have been characterized using acetylcholinesterase (AchE) histochemistry, Golgi, and electron microscopic techniques. Already, at birth, the neurons were found to be AchE-rich. They contain presumed AchE reaction product within their granular endoplasmic reticulum. These cells send fine axons upwards towards the subpial layer where they terminate in a dense, AchE-rich, fiber plexus. In chronically undercut cortex, AchE staining persists in layer VIb neurons and in the subpial fiber plexus. These observations continue to support the view that there is an intrinsic neuronal circuit connecting layer VI with I in immature neocortex. The findings also raise the possibility that the putative circuit is cholinergic.
在这项个体发育研究中，利用乙酰胆碱酯酶（AchE）组织化学、高尔基染色法和电子显微镜技术对啮齿动物体感皮层VIb层的神经元进行了特征描述。在出生时就已发现这些神经元富含AchE。它们的粗面内质网内含有假定的AchE反应产物。这些细胞发出细轴突向上伸向软膜下层，在那里它们终止于一个密集的、富含AchE的纤维丛。在慢性切断皮层中，AchE染色在VIb层神经元和软膜下纤维丛中持续存在。这些观察结果继续支持这样一种观点，即在未成熟的新皮层中存在一个将VI层与I层连接起来的内在神经元回路。这些发现还提出了一种可能性，即假定的回路是胆碱能的。
